GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | DOLK | chr9:131707810-131710012:- | -0.12 | -3.4 | 0.000708 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | DOLPP1 | chr9:131843383-131852716:+ | -0.13 | -3.77 | 0.000175 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | GLE1 | chr9:131266971-131304579:+ | -0.16 | -4.19 | 2.97E-5 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | GOLGA2 | chr9:131018109-131038268:- | -0.15 | -4.04 | 5.84E-5 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | GPR107 | chr9:132815985-132902448:+ | -0.13 | -3.95 | 8.22E-5 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | LRRC8A | chr9:131644391-131680315:+ | -0.12 | -3.38 | 0.000757 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | METTL11A | chr9:132388435-132397879:+ | -0.1 | -3.74 | 0.000191 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | NUP188 | chr9:131703724-131769374:+ | -0.15 | -4.35 | 1.47E-5 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | ODF2 | chr9:131217466-131263238:+ | -0.17 | -4.64 | 3.86E-6 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | SET | chr9:131445934-131458674:+ | -0.13 | -4 | 6.77E-5 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | SH3GLB2 | chr9:131770314-131790579:- | -0.13 | -4.85 | 1.42E-6 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | TBC1D13 | chr9:131549510-131572710:+ | -0.13 | -3.42 | 0.000648 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | TOR1A | chr9:132575222-132586441:- | -0.14 | -3.45 | 0.000584 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | USP20 | chr9:132597696-132644107:+ | -0.09 | -3.54 | 0.000418 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | WDR34 | chr9:131395940-131419129:- | -0.1 | -3.5 | 0.000485 | Blood metabolite ratios |